树枝状大分子
咖啡酸
生物相容性
化学
抗氧化剂
多酚
聚乙二醇
有机化学
咖啡酸苯乙酯
细胞毒性
药物输送
生物化学
组合化学
体外
作者
Marika Grodzicka,Cornelia E. Peña-González,Paula Ortega,Sylwia Michlewska,Rebeca Lozano,Maria Bryszewska,F. Javier de la Mata,Максим Йонов
标识
DOI:10.1016/j.susmat.2022.e00497
摘要
Dendrimers, branched polymer structures, have been widely studied as efficient drug carriers. Scientists are trying to find new dendrimer-based formulations with the properties needed for biomedical applications such as improved bioavailability, low toxicity and high transfection profiles. The unique drug delivery properties of carbosilane dendrimers have already been demonstrated. Their efficacy has been further improved by conjugation with polyphenols, plant secondary metabolites with a wide range of biological activities, including antioxidant effects that are beneficial for human health. The present study focuses on synthesis and characterization of two new types of carbosilane dendritic systems, one family presents one or two caffeic acid units and ammonium groups on the surface to make them water soluble. The other family has, in addition to the two mentioned functionalities, one or two polyethylene glycol (PEG) chains in the structure to increase the biocompatibility of the system. Carbosilane dendrimers with caffeic acid have low toxicity and protect erythrocytes against oxidative hemolysis. These dendrimers also decrease AAPH-induced ROS production in human fibroblasts. Various techniques demonstrating such antioxidant activities have been applied in the current research. The best antioxidant properties were shown for the dendrimer with two PEG-caffeic acid moieties. Further aspects of the biochemical characterization of the dendrimers are also considered and discussed.
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