Hydrazides as Potential HDAC Inhibitors: Structure-activityRelationships and Biological Implications

Abstract: Epigenetic modulations by HDACs are associated with multiple disease conditions. In this context, HDACs play vital roles in the progression of diseases including several cancers, neu-rodegenerative diseases, inflammatory diseases, and metabolic disorders. Though several HDAC inhibitors have been established as drug candidates, their usage has been restricted because of broad-spectrum inhibition, highly toxic character, and off-target adverse effects. Therefore, specific HDAC selectivity is essential to get rid of such adverse effects. Hydrazide-based compounds have already been proven to exert higher inhibitory efficacy and specific HDAC selectivity. In this arti-cle, the detailed structure-activity relationship (SAR) of the existing hydrazide-based HDAC inhibi-tors has been elucidated to gather crucial information that can be utilized further for the develop-ment of promising drug candidates for combating diverse diseases in the future.