生物污染
涂层
贻贝
纳米技术
聚合物
高分子科学
材料科学
化学工程
化学
有机化学
工程类
生态学
生物
膜
生物化学
作者
Adel S. Imbia,Artjima Ounkaew,Xiaohui Mao,Hongbo Zeng,Yang Liu,Ravin Narain
出处
期刊:Langmuir
[American Chemical Society]
日期:2024-05-16
卷期号:40 (21): 10957-10965
被引量:8
标识
DOI:10.1021/acs.langmuir.4c00326
摘要
Zwitterionic coatings provide a promising antifouling strategy against biofouling adhesion. Quaternary ammonium cationic polymers can effectively kill bacteria on the surface, owing to their positive charges. This strategy can avoid the release of toxic biocides, which is highly desirable for constructing coatings for biomedical devices. The present work aims to develop a facile method by covalently grafting zwitterionic and cationic copolymers containing aldehydes to the remaining amine groups of self-polymerized dopamine. Reversible addition–fragmentation chain transfer polymerization was used to copolymerize either zwitterionic 2-methacryloyloxyethyl phosphorylcholine monomer (MPC) or cationic 2-(methacryloyloxy)ethyl trimethylammonium monomer (META) with 4-formyl phenyl methacrylate monomer (FPMA), and the formed copolymers poly(MPC-st-FPMA) and poly(META-st-FPMA) are denoted as MPF and MTF, respectively. MPF and MTF copolymers were then covalently grafted onto the amino groups of polydopamine-coated surfaces. PDA/MPF/MTF-coated surfaces exhibited antibacterial and antifouling properties against S. aureus, E. coli, and bovine serum albumin protein. In addition, they showed excellent viability of normal human lung fibroblast cells MRC-5. We expect the facile surface modification strategy discussed here to be applicable to medical device manufacturing.
科研通智能强力驱动
Strongly Powered by AbleSci AI