自身抗体
慢性炎症性脱髓鞘性多发性神经病
医学
免疫学
多灶性运动神经病
多发性神经病
免疫系统
格林-巴利综合征
髓鞘
发病机制
病理生理学
自身免疫
抗体
病理
中枢神经系统
内科学
失配负性
脑电图
精神科
作者
Roger Collet,Marta Caballero-Ávila,Luís Querol
标识
DOI:10.1016/j.neurol.2023.02.064
摘要
Autoimmune neuropathies are a heterogeneous group of rare and disabling diseases in which the immune system targets peripheral nervous system antigens and that respond to immune therapies. This review focuses on Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, polyneuropathy associated with IgM monoclonal gammopathy, and autoimmune nodopathies. Autoantibodies targeting gangliosides, proteins in the node of Ranvier, and myelin-associated glycoprotein have been described in these disorders, defining subgroups of patients with similar clinical features and response to therapy. This topical review describes the role of these autoantibodies in the pathogenesis of autoimmune neuropathies and their clinical and therapeutic importance.
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