医学
彭布罗利珠单抗
近距离放射治疗
化疗
肿瘤科
肺癌
放射科
肺
碘
内科学
癌症
核医学
医学物理学
放射治疗
免疫疗法
材料科学
冶金
作者
Mingli Yuan,Liangchao Wang,Xiudong Yang,Guo Xiao-qun,Yi Hu
标识
DOI:10.5114/jcb.2023.125582
摘要
Although immunotherapy regimens for advanced non-small-cell lung cancer (NSCLC) improve survival in selected sub-populations, their efficacy remains far from ideal due to underlying resistance; therefore, multimodal combination strategies are needed to optimize their efficacy. In our report, two patients with advanced NSCLC with negative targetable mutations, who had failed first-line chemotherapy were treated with combined therapy of computed tomography (CT)-guided percutaneous iodine-125 seed implantation and pembrolizumab. After combination treatment, both patients achieved partial response (PR), and sustained a long progression-free survival (PFS) without obvious therapy-related adverse reactions. Iodine-125 seeds bring no long-term adverse events and effectively amplify anti-tumor immune response induced by immunotherapy; thus, this combined therapy might be a promising alternative for NSCLC.
科研通智能强力驱动
Strongly Powered by AbleSci AI