亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

pH-sensitive tumor-tropism hybrid membrane-coated nanoparticles for reprogramming the tumor microenvironment and boosting the antitumor immunity

肿瘤微环境 免疫系统 重编程 癌症研究 免疫疗法 癌症免疫疗法 癌细胞 化学 生物 细胞生物学 癌症 免疫学 细胞 生物化学 遗传学
作者
Jie Zhang,Liwen Wei,Xiaocao Ma,Jingguo Wang,Siping Liang,Kang Chen,Minhao Wu,Niu Li,Yuanqing Zhang
出处
期刊:Acta Biomaterialia [Elsevier BV]
卷期号:166: 470-484 被引量:22
标识
DOI:10.1016/j.actbio.2023.05.040
摘要

Metabolic dysregulation contributes not only to cancer development but also to a tumor immune microenvironment (TIME), which poses great challenges to chemo- and immunotherapy. Targeting metabolic reprogramming has recently emerged as a promising strategy for cancer treatment, but the lethality against solid tumors appears to be fairly restricted, partially due to the poor solubility of small molecule drugs. Herein, we construct a versatile biomimetic nanoplatform (referred to as HM-BPT) employing pH-sensitive tumor-tropism hybrid membrane-coated Manganese oxide (MnO2) nanoparticles for the delivery of BPTES, a glutamine metabolism inhibitor. Basically, hybrid membranes consisting of mesenchymal stem cell membranes (MSCm) and pH-sensitive liposomes (pSL) enable the biomimetic nanoplatform to target TME and escape from endo/lysosomes after endocytosis. The results reveal that HM-BPT treatment leads to remarkable tumor inhibition, cytotoxic T lymphocyte (CTL) infiltration, as well as M1 phenotype repolarization and stimulator of IFN genes (STING) pathway activation in macrophages in a 4T1 xenograft model. Furthermore, glutathione (GSH) depletion and oxygen (O2) supply synergistically ameliorate the immunosuppressive status of the TME, boosting potent antitumor immune responses. Overall, our study explores an integrated therapeutic platform for TME reprogramming and immune activation, offering tremendous promise for cancer combination therapy. Metabolic abnormalities and the tumor immune microenvironment (TIME) lead to hyporesponsiveness to conventional therapies, ultimately resulting in refractory malignancies. In the current work, a biomimetic nanoplatform (HM-BPT) was developed for TME metabolic reprogramming in favor of immunotherapy. Particularly, hybrid membrane camouflage endowed the nanoplatform with TME targeting, endo/lysosomal escape, and sensitive release properties. The impact of hybrid membrane fusion ratio on cellular uptake and cell viability was explored, yielding beneficial references for the future development of bioactive nanomaterials. Intravenous administration of HM-BPT substantially relieved tumor burden and restored innate and acquired immune activation in 4T1 xenograft models. In conclusion, the created HM-BPT system has the potential to be a promising nanoplatform for combining cancer therapies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
干净的时光完成签到,获得积分10
3秒前
乐乐应助kash想毕业采纳,获得10
4秒前
汉堡包应助wop111采纳,获得10
7秒前
乐乐应助布鲁爱思采纳,获得10
7秒前
18秒前
20秒前
24秒前
布鲁爱思发布了新的文献求助10
24秒前
旺旺咪完成签到,获得积分10
28秒前
唐泽雪穗应助魔幻的雪碧采纳,获得10
35秒前
羞涩的傲菡完成签到,获得积分10
35秒前
1分钟前
周哲应助唐泽雪穗采纳,获得110
1分钟前
GingerF应助科研通管家采纳,获得150
1分钟前
huminjie发布了新的文献求助20
1分钟前
周哲应助唐泽雪穗采纳,获得100
1分钟前
胡可完成签到 ,获得积分10
1分钟前
周哲应助唐泽雪穗采纳,获得40
1分钟前
王思蒙完成签到 ,获得积分10
2分钟前
李健的粉丝团团长应助aa采纳,获得10
2分钟前
2分钟前
2分钟前
2分钟前
火星完成签到 ,获得积分10
2分钟前
2分钟前
量子星尘发布了新的文献求助10
2分钟前
wop111发布了新的文献求助10
2分钟前
2分钟前
2分钟前
小蘑菇应助wop111采纳,获得10
2分钟前
2分钟前
休斯顿完成签到,获得积分10
2分钟前
aa发布了新的文献求助10
2分钟前
2分钟前
2分钟前
3分钟前
Lutras发布了新的文献求助10
3分钟前
3分钟前
3分钟前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zur lokalen Geoidbestimmung aus terrestrischen Messungen vertikaler Schweregradienten 1000
Schifanoia : notizie dell'istituto di studi rinascimentali di Ferrara : 66/67, 1/2, 2024 1000
Circulating tumor DNA from blood and cerebrospinal fluid in DLBCL: simultaneous evaluation of mutations, IG rearrangement, and IG clonality 500
Food Microbiology - An Introduction (5th Edition) 500
Architectural Corrosion and Critical Infrastructure 400
Laboratory Animal Technician TRAINING MANUAL WORKBOOK 2012 edtion 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4858498
求助须知:如何正确求助?哪些是违规求助? 4154218
关于积分的说明 12874380
捐赠科研通 3904687
什么是DOI,文献DOI怎么找? 2145377
邀请新用户注册赠送积分活动 1164503
关于科研通互助平台的介绍 1065848