医学
癌症
流行病学
入射(几何)
人口
疾病
拉丁美洲
内科学
人口学
肿瘤科
胃肠病学
环境卫生
政治学
法学
物理
社会学
光学
作者
María José López,Junior Carbajal,Alejandro Alfaro,Luis G. Saravia,Eusebio D. Zanabria,Jhajaira M. Araujo,Lidia Quispe,Karla A. Vizcarra,José L. Buleje,Christina Eunbee Choo,Marisol Sarmiento,Joseph A. Pinto,Williams Fajardo
标识
DOI:10.1016/j.critrevonc.2022.103841
摘要
Gastric cancer is one of the most important malignancies in the world due to the high burden of disease and lethality. In this work, we compared the main characteristics of gastric cancer between different regions of the world. We reviewed public repositories to retrieve epidemiological, molecular, clinicopathological, and risk factor data. Eastern Asia presents the highest incidence of gastric cancer, followed by eastern and central Europe. Intestinal histology was more frequent in Caucasians, while gastric tumors located in the cardias were less frequent in Africa and Latin America. TP53, LRP1B, and ARID1A are consistently the most frequently altered genes in all population groups. Gastric cancer is most frequent in men. African patients tend to be younger and have a higher proportion of women patients. Different patterns can be observed in the presentation of gastric cancer between different regions of the world. More research is needed in Latin America and Africa since these populations are underrepresented.
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