TPDdb: the comprehensive database of targeted protein degrader

Targeted protein degraders (TPDs) have emerged in the past decade as a new drug modality of transformative paradigm, offering a powerful strategy to catalytically remove disease-relevant proteins, especially those long considered as "undruggable." With the rapid advancement in this direction, there is increasing demand for a database describing TPDs. Herein, a comprehensive database of TPDs, titled TPDdb, was therefore developed. TPDdb is unique in (i) covering the largest amount of TPDs among existing databases (6002 Molecular Glues, 22 183 PROTACs, 249 LYTACs, 169 ATTECs, 29 AUTOTACs, and 23 AUTACs targeting 580 proteins of interest and associated with 274 diseases) with their structural and physicochemical properties offered; (ii) describing 27 796 activities (IC50, DC50, Dmax, etc.) for all collected TPDs related to 201 cell lines; and (iii) providing the structures of TPDs, proteins of interest, ligase, and experimentally determined ternary complexes. TPDdb is now accessible at https://idrblab.org/TPDdb/.