Tenecteplase or alteplase for acute ischemic stroke beyond 4.5 hours of last known well: A pooled analysis of the TETRIS and EVATRISP registries

The functional outcomes of patients LKW > 4.5 h treated with tenecteplase or alteplase did not significantly differ in this pooled analysis of two observational registries. However, the direction of the associations did not favor tenecteplase over alteplase, and therefore, more comparative studies-ideally randomized-are needed before routinely switching to tenecteplase in this population.