化学
质谱法
异氰酸酯
环氧乙烷
串联质谱法
环氧丙烷
硼烷
多元醇
表征(材料科学)
共聚物
超临界流体
聚氨酯
聚合物
色谱法
催化作用
有机化学
纳米技术
材料科学
作者
Anthony P. Gies,David M. Hercules,Arjun Raghuraman,Alex J. Kosanovich,Matthew A. Baker,S. Mukhopadhyay,Ilia J. Kobylianskii,Manjiri Paradkar
摘要
Abstract This article reviews the analytical tool chest used for characterizing alkoxylates and their associated copolymer mixtures. Specific emphasis will be placed upon the use of mass spectrometry‐based techniques as rapid characterization tools for optimizing reaction processes in an industrial R&D setting. An initial tutorial will cover the use of matrix‐assisted laser desorption/ionization‐mass spectrometry and tandem mass spectrometry fragmentation for detailed component analysis (e.g., polyol and isocyanate) of a model polyurethane‐based foam. Next, this critical feedback information will be used with the guidance of mass spectrometry to initiate the development of a new, more efficient, tris(pentafluorophenyl)borane (FAB) catalyst‐based alkoxylation process for generating the next generation of glycerin‐initiated poly(propylene oxide)‐ co ‐poly(ethylene oxide) copolymers. Examples will be provided for each step in the FAB‐based optimization process that were required to generate the final product. Following this example, two‐dimensional liquid chromatography, supercritical fluid chromatography, and ion mobility separations, along with their coupling to mass spectrometry, will be reviewed for their efficiency in characterizing and quantitating the components within these complex polyether polyol mixtures.
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