纳米颗粒
背景(考古学)
纳米材料
纳米技术
Zeta电位
表征(材料科学)
碳水化合物
材料科学
化学
纳米医学
生物化学
生物
古生物学
作者
Leonard Krupnik,Prachi Joshi,Andreas Kappler,Beat Flühmann,Amy Barton Alston,Reinaldo Digigow,Peter Wick,Antonia Neels
标识
DOI:10.1016/j.ejps.2023.106521
摘要
Intravenous iron-carbohydrate nanomedicines are widely used to treat iron deficiency and iron deficiency anemia across a wide breadth of patient populations. These colloidal solutions of nanoparticles are complex drugs which inherently makes physicochemical characterization more challenging than small molecule drugs. There have been advancements in physicochemical characterization techniques such as dynamic light scattering and zeta potential measurement, that have provided a better understanding of the physical structure of these drug products in vitro. However, establishment and validation of complementary and orthogonal approaches are necessary to better understand the 3-dimensional physical structure of the iron-carbohydrate complexes, particularly with regard to their physical state in the context of the nanoparticle interaction with biological components such as whole blood (i.e. the nano-bio interface).
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