化学
生物利用度
持久性(不连续性)
鉴定(生物学)
药物发现
药理学
计算生物学
生物化学
生物
生态学
工程类
岩土工程
标识
DOI:10.1021/acs.jmedchem.1c02108
摘要
Over the past two decades, Factor XIa inhibitors have emerged as an exciting new class of antithrombic agents. Identification of orally bioavailable small molecule inhibitors has presented a formidable challenge for medicinal chemists. Herein, those challenges and the problem-solving that resulted in the discovery of milvexian will be presented.
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