克拉斯
药物发现
化学
癌基因
癌症
计算生物学
小分子
癌症研究
小型GTPase
药理学
突变
遗传学
基因
生物
信号转导
生物化学
细胞周期
作者
Qinheng Zheng,D. Matthew Peacock,Kevan M. Shokat
标识
DOI:10.1021/acs.jmedchem.2c00099
摘要
Since its discovery as the first human oncogene in 1983, the small GTPase KRAS has been a major target of cancer drug discovery. The paper reported in this issue describes a long-awaited small molecule drug candidate of the oncogenic KRAS (G12D) mutant for the treatment of currently incurable pancreatic cancer.
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