Enzyme-promoted oxidative cross-coupling for the synthesis of oxyresveratrol-related heterodimers

Horseradish peroxidase–H 2 O 2 -mediated oxidative cross-coupling reactions of oxyresveratrol 2-methyl ether and brominated isorhapontigenin or brominated resveratrol efficiently produce two 8-5’-coupled dihydrobenzofuran-type heterodimers. The LiAlH 4 -catalysed reductive debrominations of these cross-coupled dimeric intermediates provided the first synthesis of two unnatural oxyresveratrol-related heterodimers.