材料科学
微加工
制作
计算机科学
纳米技术
医学
病理
替代医学
作者
Sang‐Heon Lee,Martin Thunemann,Keundong Lee,Daniel R. Cleary,Karen J. Tonsfeldt,Hongseok Oh,Farid Azzazy,Youngbin Tchoe,Andrew M. Bourhis,Lorraine Hossain,Yun Goo Ro,Atsunori Tanaka,Kıvılcım Kılıç,Anna Devor,Shadi A. Dayeh
标识
DOI:10.1002/adfm.202112045
摘要
The Utah array powers cutting-edge projects for restoration of neurological function, such as BrainGate, but the underlying electrode technology has itself advanced little in the last three decades. Here, advanced dual-side lithographic microfabrication processes is exploited to demonstrate a 1024-channel penetrating silicon microneedle array (SiMNA) that is scalable in its recording capabilities and cortical coverage and is suitable for clinical translation. The SiMNA is the first penetrating microneedle array with a flexible backing that affords compliancy to brain movements. In addition, the SiMNA is optically transparent permitting simultaneous optical and electrophysiological interrogation of neuronal activity. The SiMNA is used to demonstrate reliable recordings of spontaneous and evoked field potentials and of single unit activity in chronically implanted mice for up to 196 days in response to optogenetic and to whisker air-puff stimuli. Significantly, the 1024-channel SiMNA establishes detailed spatiotemporal mapping of broadband brain activity in rats. This novel scalable and biocompatible SiMNA with its multimodal capability and sensitivity to broadband brain activity will accelerate the progress in fundamental neurophysiological investigations and establishes a new milestone for penetrating and large area coverage microelectrode arrays for brain-machine interfaces.
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