Ruscogenin Alleviates Deep Venous Thrombosis and Pulmonary Embolism Inducedby Inferior Vena Cava Stenosis Inhibiting MEK/ERK/Egr-1/TF Signaling Pathwayin Mice

IVCS model contributed to the development of DVT and PE in mice and was associated with increased inflammation. RUS showed therapeutic effects by inhibiting inflammation as well as suppressing the activation of MEK/ERK/Egr-1/TF signaling pathway.