生物
RNA聚合酶Ⅱ
抄写(语言学)
遗传学
转录因子
RNA聚合酶Ⅲ
计算生物学
转录调控
基因
RNA聚合酶
细胞生物学
核糖核酸
基因表达
发起人
语言学
哲学
作者
Abderhman Abuhashem,Vidur Garg,Anna-Katerina Hadjantonakis
出处
期刊:Open Biology
[The Royal Society]
日期:2022-01-01
卷期号:12 (1)
被引量:20
摘要
The coordinated regulation of transcriptional networks underpins cellular identity and developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) is a prevalent mechanism by which cells can control and synchronize transcription. Pol II pausing regulates the productive elongation step of transcription at key genes downstream of a variety of signalling pathways, such as FGF and Nodal. Recent advances in our understanding of the Pol II pausing machinery and its role in transcription call for an assessment of these findings within the context of development. In this review, we discuss our current understanding of the molecular basis of Pol II pausing and its function during organismal development. By critically assessing the tools used to study this process we conclude that combining recently developed genomics approaches with refined perturbation systems has the potential to expand our understanding of Pol II pausing mechanistically and functionally in the context of development and beyond.
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