[Hormone replacement Up-to-date. LOH and testosterone replacement therapy: clinical application].

Promoting health and preventing disease requires a thorough understanding of the complexity of social and behavioral factors that affect the health of individuals and condition of communities. The concept of age-related androgen deficiency in men, also termed late-onset hypogonadism (LOH) has opened up public awareness of the significance of men's health. Low testosterone levels affect physical, mental and sexual activities, manifesting a loss of muscle mass and bone strength, increased body fat, decreased energy, less interest in sex, erectile dysfunction, irritability and depression. Although testosterone replacement therapy is needed for LOH, holistic approach including changing herbal medicine, lifestyle, proper diet, regular exercise, good relationship with the partner should be considered.