睡眠剥夺
免疫系统
呼吸道
免疫学
睡眠(系统调用)
医学
贫困
病毒
干扰素
呼吸系统
免疫
病毒学
昼夜节律
内科学
计算机科学
操作系统
作者
Kathryn B. Renegar,Dennis T. Crouse,R. A. Floyd,James M. Krueger
出处
期刊:Sleep
[Oxford University Press]
日期:2000-10-01
卷期号:23 (7): 1-5
被引量:33
摘要
Sleep deprivation is reported to have both beneficial and harmful effects upon host defenses. In the work reported herein, we address the effects of sleep deprivation on the mucosal anti-influenza defenses of both immune and nonimmune BALB/c mice. Sleep deprivation does not depress existing mucosal antiviral defenses in the respriatory tracts of BALB/c mice; in fact, it may actually be beneficial. Nasal mucosal immunity is not adversely affected in immune mice by sleep deprivation. In nonimmune mice, sleep deprivation slows or prevents the progress of nasal influenza viral infection down the trachea into the lungs. By 72 hours post-infection, 12 of 12 control mice shed virus into bronchioalveolar lavages (BAL) while only 2 of 12 sleep deprived mice shed virus (p<0.001). BAL levels of IL-1ß and interferon α were increased in sleep deprived animals, suggesting that sleep deprivation may exert its beneficial effects on the respiratory tract by upregulating the production of antiviral cytokines.
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