医学
清洁剂
光老化
皮肤病科
不利影响
安全概况
面部修复
养生
外科
内科学
病理
作者
Mehta Rc,Stacy Smith,Grove Gl,Ford Ro,W Canfield,Donofrio Lm,Flynn Tc,Leyden Jj
出处
期刊:PubMed
日期:2008-09-01
卷期号:7 (9): 864-71
被引量:14
摘要
A topical gel containing a proprietary mixture of over 110 growth factors, cytokines, and soluble matrix proteins secreted by human dermal fibroblasts was evaluated for safety and efficacy in the treatment of mild to severe facial photodamage. In a double-blind study, 60 subjects were randomly assigned to receive either active gel or the vehicle and applied twice daily for 6 months along with a moisturizing cleanser and sunscreen. Efficacy (profilometry, photography, and clinical assessment) and safety (adverse event reporting) measures were evaluated at 0, 3, and 6 months. Treatment with the active gel for 3 months produced greater reduction in fine lines and wrinkles than the vehicle treatment as measured by objective and subjective assessment techniques. The results were either statistically significant (P < or = .05) or trending towards statistical significance (P < or = .1). This study demonstrates that addition of a topical formulation of growth factors and cytokines to a basic skin care regimen reduces the signs of photoaging.
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