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Type I IFNs and TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation
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部分正文内容：Cross-regulation of Toll-like receptor responses by cytokines is essential for effective host defense, avoidance of toxicity, and homeostasis, but the underlying mechanisms are not well understood. A comprehensive epigenomic approach in human macrophages showed that the proinflammatory cytokines TNF and type I IFNs induce transcriptional cascades that alter chromatin states to broadly reprogram TLR4-induced responses. TNF tolerized inflammatory genes to prevent toxicity, while preserving antiviral and metabolic gene |
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(2025-6-4)
大力的灵雁
Criminology34
鸟兽兽
GingerF
三四郎
eric888
OsamaKareem
YifanWang
无极微光
张欢馨
脆蜜金桔
yorha3h
Joyce
hsa_ID
arniu2008
Shawndy
loii
Mic
干净的琦
初景
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