| 标题 |
Multimodal clocks of human aging 相关领域
溃疡性结肠炎
医学
人口
炎症性肠病
入射(几何)
克罗恩病
系统回顾
流行病学
疾病
内科学
梅德林
环境卫生
政治学
光学
物理
法学
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| 网址 | |
| DOI |
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10.1016/s0140-6736(17)32448-0
Doi
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| 其它 |
PMID: 42105758 DOI: 10.1016/j.cell.2026.04.025 Abstract Human aging is characterized by complex structural and functional decline, but quantifying its heterogeneity and assessing biological age remain challenges. We present the mCAS developed from 2,019 Chinese individuals aged 18-91 years. Integrating high-dimensional clinical, physiological, and molecular-level data, we constructed a three-tiered aging framework: the CC-clock to quantify clinical physiological decline, the MM-clock with extensive parameter coverage and enhanced predictive precision, and organ-associated aging clocks. This study provides a foundational framework that bridges molecular signatures with functional decline, identifies new biomarkers for aging assessment, and reveals a novel translational driver of aging.这是部分摘要,因字数限制 |
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(2025-6-4)