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Structural characterization of the therapeutic monoclonal antibody trastuzumab by LC /MS and LC/MS
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Author(s): Henry Shion, Asish Chakraborty, YU Ying-qing, CHEN Xi, SUN Qing-long, Scott Berger, CHEN Wei-bin, SONG Lan-kun, Waters Corporation, Waters Technology Co., Ltd. Pages: 418-426+431 Year: 2014 Issue: 4 Journal: Chinese Journal of New Drugs Keyword: trastuzumab; mAb; sequence variants; post translational modifications; PTMs; N-linked glycosylation; oligosaccharides; micro-heterogeneities; antibody characterization; intact protein mass measurement; peptide mapping; sequence coverage; sugar chain analysis; 2-AB labeled; UPLC / QTof MS; LC / MS; LC / MSE; Biopharm; |
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