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Rapid UPF1 depletion illuminates the temporaldynamics of the NND-regulated humantranscriptome
UPF1的快速耗竭阐明了NND调节的人类转录组的时间动力学
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Authors Volker Boehm, Damaris Wallmeroth,Paul O. Wulf, .., Philipp Mertins,Markus Landthaler, Niels H. Gehring Correspondencemarkus.landthaler@mdc-berlin.de (M.L.).ngehring@uni-koeln.de(N.H.G.) In brief UPF1 depletion inhibits nonsense mediated mRNA decay (NMD) andstabilizes direct target transcripts withinhours. Boehm et al. use conditionaprotein degradation and advancedtranscriptomics to map the NMD.regulated human transcriptome,highlighting alternative splicing as amajor NMD-activating mechanism. |
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(2025-6-4)