| 标题 |
Targeting TROP-2 In Diffuse Pleural Mesothelioma
TROP-2靶向治疗弥漫性胸膜间皮瘤
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M.D. Offin , S. Tischfield , P. Manoj , P. Agrawal , S. Tendler , E.C. Pratt , W. Travis , A. Rimner , C.B. Simone , E. de Stanchina , J. Qiu , V. Markov , M. Donoghue , J.S. Lewis , M.G. Kris , J.L. Sauter , P.S. Adusumilli , C.M. Rudin , A. Quintanal Villalonga , M.G. Zauderer Show more Add to Mendeley Share Cite https://doi.org/10.1016/j.jtho.2024.09.125 Get rights and content Introduction Diffuse pleural mesothelioma (DPM) is a nearly universally fatal malignancy with limited treatment options. There is a lack of validated biomarkers, other than histology, and no approved targeted strategies. Utilizing our patient derived xenograft (PDX) library, we identified TROP-2 as a candidate target. TROP-2 expression has been shown to correlate with tumorigenesis in several solid tumors but has not been adequately assessed in DPM. |
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(2025-6-4)
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