| 标题 |
[求助补充材料]
  Probiotic-based nanoparticles for targeted microbiota modulation and immune restoration in bacterial pneumonia 基于益生菌的纳米粒子用于细菌性肺炎的靶向微生物群调节和免疫恢复
相关领域
免疫调节
免疫系统
微生物学
益生菌
生物
肺炎
细菌性肺炎
免疫学
细菌
医学
抗生素
遗传学
内科学
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| 网址 | |
| DOI | |
| 其它 |
While conventional bacterial pneumonia mainly centralizes avoidance of bacterial colonization, it remains unclear how to restore the host immunity for hyperactive immunocompetent primary and immunocompromised secondary bacterial pneumonia. Here, probiotic-based nanoparticles of OASCLR were formed by coating chitosan, hyaluronic acid and ononin on living Lactobacillus rhamnosus. OASCLR nanoparticles could effectively kill various clinic common pathogens and antibacterial efficiency was >99.97%. Importantly, OASCLR could modulate lung microbiota, increasing the overall richness and diversity of microbiota by decreasing pathogens and increasing probiotic and commensal bacteria. |
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