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[The immunomodulatory effect of neutrophil extracellular trapping nets (NETs) on hematological diseases]
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Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology Pub Date : 2022-04-01 Mei Huang , Shiyu Wang , Zhengdong Hao , Xiaojia Guo , Songlin Chu , Lijuan Li , Liansheng Zhang Neutrophil extracellular traps (NETs) are characterized by a extracellular fibrous network structure produced by neutrophils with DNA and proteins. NETs can be formed by NADPH-dependent NETosis and NADPH-independent NETosis. After formation, it is not only hydrolyzed by DNase in plasma but can also be degraded intracellularly and extracellularly by macrophages and dendritic cells. Recent researches on NETs have reported the increased expression of NETs in a variety of hematological diseases and its immunomodulatory effect on blood system diseases. For example, NETs are closely linked to infections related to leukemia treatment, which affects the treatment and prognosis of leukemia |
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(2025-6-4)
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