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An efficient preparation of a terminal arylacetylene
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| 其它 | In the past, synthetic routes to arylacetylenes via cross-coupling reactions of expensive monosubstituted acetylenes, such as (trimethylsilyl)acetylene, using Pd(0) reagents have been the commonly used practice. Due to the high costs of such monosubstituted acetylenes, these routes are usually limited to small-scale preparations An alternative route for the introduction of a protected ethynyl moiety may be via the use of 2-hydroxypropan-2-yl by way of the inexpensive reagent 2-methyl-3-butyn-2-ol. Subsequent hydrolysis and deprotection can then generate the terminal acetylene group. However, the seemingly attractive 2-methyl-3-butyn-2-ol reagent was not so effective because deprotection via removal of 2-hydroxypropan-2-yl was more complicated than at first appeared. Thus, the traditional method of using (trimethylsilyl)acetylene was proved to be the more effective way of introducing a terminal arylacetylene group. |
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(2025-6-4)
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