透皮
角质层
材料科学
药物输送
胶粘剂
生物医学工程
透皮贴片
药品
明胶
纳米技术
渗透(战争)
离子导入
药理学
医学
化学
图层(电子)
运筹学
病理
工程类
放射科
生物化学
作者
Moonjeong Bok,Zhi‐Jun Zhao,Sung Hwan Hwang,Yongrok Jeong,Jiwoo Ko,Junseong Ahn,Ju Ho Lee,Sohee Jeon,Jun‐Ho Jeong
标识
DOI:10.1021/acsami.1c18750
摘要
Patch-type drug delivery has garnered increased attention as an attractive alternative to the existing drug delivery techniques. Thus far, needle phobia and efficient drug delivery remain huge challenges. To address the issue of needle phobia and enhance drug delivery, we developed a needle-free and self-adhesive microcup patch that can be loaded with an ultrathin salmon DNA (SDNA) drug carrier film. This physically integrated system can facilitate efficient skin penetration of drugs loaded into the microcup patch. The system consists of three main components, namely, a cup that acts as a drug reservoir, an adhesive system that attaches the patch to the skin, and physical stimulants that can be used to increase the efficiency of drug delivery. In addition, an ultrathin SDNA/drug film allows the retention of the drug in the cup and its efficient release by dissolution in the presence of moisture. This latter feature has been validated using gelatin as a skin mimic. The cup design itself has been validated by comparing its deformation and displacement with those of a cylindrical structure. Integration of the self-adhesive microcup patch with both ultrasonic waves and an electric current allows the model drug to penetrate the stratum corneum of the skin barrier and the whole epidermis, thereby enhancing transdermal drug delivery and reducing skin irritation. This system can be used as a wearable biomedical device for efficient transdermal and needle-free drug delivery.
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