非编码RNA
生物
计算生物学
癌变
核糖核酸
机制(生物学)
小RNA
小核仁RNA
长非编码RNA
癌症
基因组学
生物信息学
遗传学
基因组
基因
哲学
认识论
作者
Sarra Setrerrahmane,Mengwei Li,Abdelmoumin Zoghbi,Xue Lv,Sen Zhang,Wenjing Zhao,Jingjing Lu,David J. Craik,Hanmei Xu
出处
期刊:Cancer Letters
[Elsevier]
日期:2022-10-01
卷期号:547: 215723-215723
被引量:16
标识
DOI:10.1016/j.canlet.2022.215723
摘要
An exciting emerging topic in the noncoding RNA (ncRNA) field is the discovery of short peptides called micropeptides (≤100 amino acids), whose novel therapeutic opportunities remain under-explored. Micropeptides have been suggested to play essential regulatory roles in diverse species of physiological and pathological processes. Genomics studies have revealed that these micropeptides are encoded by small open reading frames (sORFs) concealed in misannotated ncRNAs, generally lncRNAs (long noncoding RNAs) and circRNAs (circular RNAs). These ncRNA-encoded micropeptides have been shown to contribute to tumorigenesis but little is known about their pathological mechanism because of challenges in translated sORF identification techniques. Here, we review the best-validated micropeptides involved in the progression of human tumors and discuss their therapeutic and/or prognostic potential, at the same time, we also give our own suggestions on the concept of potential-coding RNA and micropeptides.
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