作者
Dusan Bogunovic,Minji Byun,Larissa A. Durfee,Avinash Abhyankar,Özden Sanal,Davood Mansouri,Sandra Salem,Irena Radovanovic,Audrey V. Grant,Parisa Adimi,Nahal Mansouri,Satoshi Okada,Vanessa L. Bryant,Xiao‐Fei Kong,Alexandra Kreins,Marcela Moncada Velez,Bertrand Boisson,Soheila Khalilzadeh,Uğur Özçeli̇k,Ilad Alavi Darazam,John W. Schoggins,Charles M. Rice,Saleh Al‐Muhsen,Marcel A. Behr,Guillaume Vogt,Anne Puel,Jacinta Bustamante,Philippe Gros,Jon M. Huibregtse,Laurent Abel,Stéphanie Boisson–Dupuis,Jean‐Laurent Casanova
摘要
Tuberculosis Vaccine Conundrum Some children experience severe clinical disease when they are vaccinated against tuberculosis, an attenuated live vaccine that is normally innocuous in humans. Several germline mutations have been identified that account for this susceptibility, and now Bogunovic et al. (p. 1684 , published online 2 August) add another to the list— ISG15 . Uncovering this mutation, which is inherited in an autosomal recessive manner, was a surprise because studies with mice deficient in ISG15 showed enhanced susceptibility to some viral, but not bacterial, infections. Nevertheless, patients lacking ISG15 were not able to produce adequate amounts of interferon-γ, a cytokine critical for clearance of the bacteria.