自噬体
自噬
细胞生物学
内体
溶酶体
细胞质
脂质双层融合
小泡
细胞器
生物
胞浆
化学
生物化学
膜
细胞内
酶
细胞凋亡
作者
Fulvio Reggiori,Christian Ungermann
标识
DOI:10.1016/j.jmb.2017.01.002
摘要
Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related proteins. These support the generation and conversion of an open membranous cistern known as the phagophore or isolation membrane into a closed autophagosome. Within this review, we will focus on recent insights into the molecular events following the sealing/completion of an autophagosome, which lead to its maturation and subsequent fusion with endosomes/lysosomes.
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