纳米囊
药物输送
药品
阿霉素
纳米颗粒
细胞
材料科学
纳米技术
毒品携带者
癌症研究
巨噬细胞
生物物理学
药理学
生物医学工程
体外
化学
化疗
医学
生物
生物化学
外科
作者
Weizhong Zhang,Mengzhe Wang,Wei Tang,Ru Wen,Shi-Yi Zhou,Chaebin Lee,Hui Wang,Wen Qi Jiang,Ian Delahunty,Zipeng Zhen,Hongmin Chen,Matthew R. Chapman,Zhanhong Wu,Elizabeth W. Howerth,Houjian Cai,Zibo Li,Jin Xie
标识
DOI:10.1002/adma.201805557
摘要
Abstract Macrophages hold great potential in cancer drug delivery because they can sense chemotactic cues and home to tumors with high efficiency. However, it remains a challenge to load large amounts of therapeutics into macrophages without compromising cell functions. This study reports a silica‐based drug nanocapsule approach to solve this issue. The nanocapsule consists of a drug–silica complex filling and a solid silica sheath, and it is designed to minimally release drug molecules in the early hours of cell entry. While taken up by macrophages at high rates, the nanocapsules minimally affect cell migration in the first 6–12 h, buying time for macrophages to home to tumors and release drugs in situ. In particular, it is shown that doxorubicin (Dox) as a representative drug can be loaded into macrophages up to 16.6 pg per cell using this approach. When tested in a U87MG xenograft model, intravenously (i.v.) injected Dox‐laden macrophages show comparable tumor accumulation as untreated macrophages. Therapy leads to efficient tumor growth suppression, while causing little systematic toxicity. This study suggests a new cell platform for selective drug delivery, which can be readily extended to the treatment of other types of diseases.
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