溃疡性结肠炎
基因型
胃肠病学
基因
发起人
结肠炎
生物
单链构象多态性
内科学
分子生物学
医学
免疫学
基因表达
遗传学
聚合酶链反应
疾病
作者
Tomiyasu Arisawa,Tomomitsu Tahara,Tomoyuki Shibata,Mitsuo Nagasaka,Masakatsu Nakamura,Yoshio Kamiya,Hiroshi Fujita,Daisuke Yoshioka,Masaaki Okubo,Mikiju Sakata,Fangyu Wang,Ichiro Hirata,Hiroshi Nakano
出处
期刊:PubMed
日期:2008-07-11
卷期号:55 (82-83): 394-7
被引量:27
摘要
Transcription factor Nrf2 regulates the expression of detoxifying and antioxidant genes. Three promoter polymorphisms of this gene have been identified. This study attempted to clarify the relationship between Nrf2 gene polymorphism and ulcerative colitis in a Japanese population.The study was performed in 89 patients with ulcerative colitis (mean age: 40.2 years, M:F = 47:42) and 141 healthy volunteers (mean age: 38.7 years, M:F = 75:66). The PCR-SSCP method was employed to detect Nrf2 polymorphisms using DNA extracted from peripheral blood cells.Comparison of genotype frequency, -686*-684 A* G/A*G genotype was significantly lower in the UC group than those in the HC group (OR = 0.45, 95% CI:0.22-0.93, p = 0.029) and G*G carrier was higher in the UC group, especially in female subjects. Furthermore, -686*-684 G*G carrier was more closely associated with chronic continuous phenotype (OR = 2.57, 95% CI:1.01-6.60, p = 0.043). On the other hand, no association between -650 genotype and ulcerative colitis was found.The -686*-684 genotype of Nrf2 gene may be associated with the development of ulcerative colitis.
科研通智能强力驱动
Strongly Powered by AbleSci AI