Chemistry of Diazabicycloundecene (DBU) and Other Pyrimidoazepines

Publisher Summary This chapter focuses on the chemistry of diazabicycloundecene (DBU) and other pyrimidoazepines. The general family of pyrimidoazepines encompasses seven distinct heterocyclic systems. This chapter illustrates that on the pyrimido azepines, the chemistry of 2,3,4,6,7,8,9,10-octahydropyrimi azepine, generally called diazabicyclo is treated in a separate subsection, as DBU has proved to be a useful reagent in synthetic organic chemistry and an important catalyst in the synthesis of macromolecules. The applications of DBU have rapidly increased because of its favorable nonnucleophilic, yet strongly basic, properties. It can therefore be applied for the preparation of even relatively sensitive molecules. This chapter also discusses the synthesis, reactions, physicochemical properties, and briefly the applications of further pyrimido[1,2-a]azepine derivatives. This chapter concludes that the treatment of the chemistry of the other pyrimidoazepines follows an essentially identical pattern to that for the pyrimido azepines.