自噬
败血症
炎症
疾病
医学
程序性细胞死亡
平衡
病态的
免疫学
细胞凋亡
生物
细胞生物学
病理
遗传学
作者
Jiayao Zhao,Qun Li,Chunhua Fu,Dalong Cong,Long Wang,Xiaoxin Xu
标识
DOI:10.1016/j.cellsig.2023.110867
摘要
Sepsis-induced acute lung injury (ALI) is a life-threatening syndrome with high mortality and morbidity, resulting in a heavy burden on family and society. As a key factor that maintains cellular homeostasis, autophagy is regarded as a self-digesting process by which damaged organelles and useless proteins are recycled for cell metabolism, and it thus plays a crucial role during physiological and pathological processes. Recent studies have indicated that autophagy is involved in the pathophysiological process of sepsis-induced ALI, including cell apoptosis, inflammation, and mitochondrial dysfunction, which indicates that regulating autophagy may be beneficial for this disease. However, the role of autophagy in the etiology and treatment of sepsis-induced ALI is not well characterized. This review summarizes the autophagy-related signaling pathways in sepsis-induced ALI, as well as focuses on the dual role of autophagy and its regulation by non-coding RNAs during disease progression, for the development of potential therapeutic strategies in this disease.
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