酞菁
光动力疗法
化学
溶解度
光化学
光敏剂
离子键合
体内
组合化学
有机化学
离子
生物技术
生物
作者
İpek Ömeroğlu,Mahmut Durmuş
出处
期刊:Turkish Journal of Chemistry
[Scientific and Technological Research Council of Turkey]
日期:2023-10-31
卷期号:47 (5): 837-863
标识
DOI:10.55730/1300-0527.3583
摘要
Photodynamic therapy (PDT) is based on a photochemical reaction that is started when a photosensitizing process is activated by the light and results in the death of tumor cells. Solubility is crucial in PDT applications to investigate the physical and chemical characteristics of phthalocyanines, but, unfortunately, most phthalocyanines show limited solubility especially in water. To increase the solubility of phthalocyanines in polar solvents and water, ionic groups such as -SO3 - , -NR3 +, -COO- , and nonionic groups such as poly-oxy chains are frequently added to the peripheral or nonperipheral positions of the phthalocyanine framework. Since water-solubility and NIR-absorbing properties are essential for efficient PDT activation, studies have been focused on the synthesis of these types of phthalocyanine derivatives. This review focuses on the photophysical, photochemical, and some in vitro or in vivo studies of the recently published ionic and nonionic phthalocyanine-mediated photosensitizers carried out in the last five years. This review will have positive contributions to future studies on phthalocyanine chemistry and their PDT applications as well as photochemistry
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