白质
自闭症谱系障碍
神经科学
光谱紊乱
自闭症
心理学
神经发育障碍
默认模式网络
功能磁共振成像
功能连接
磁共振成像
精神科
医学
放射科
作者
Kai Chen,Wenwen Zhuang,Yanfang Zhang,Shunjie Yin,Yinghua Liu,Yuan Chen,Xiaodong Kang,Hailin Ma,Tao Zhang
出处
期刊:Cerebral Cortex
[Oxford University Press]
日期:2023-10-17
卷期号:33 (24): 11582-11593
标识
DOI:10.1093/cercor/bhad392
摘要
Abstract Autism spectrum disorder is a neurodevelopmental disorder whose core deficit is social dysfunction. Previous studies have indicated that structural changes in white matter are associated with autism spectrum disorder. However, few studies have explored the alteration of the large-scale white-matter functional networks in autism spectrum disorder. Here, we identified ten white-matter functional networks on resting-state functional magnetic resonance imaging data using the K-means clustering algorithm. Compared with the white matter and white-matter functional network connectivity of the healthy controls group, we found significantly decreased white matter and white-matter functional network connectivity mainly located within the Occipital network, Middle temporo-frontal network, and Deep network in autism spectrum disorder. Compared with healthy controls, findings from white-matter gray-matter functional network connectivity showed the decreased white-matter gray-matter functional network connectivity mainly distributing in the Occipital network and Deep network. Moreover, we compared the spontaneous activity of white-matter functional networks between the two groups. We found that the spontaneous activity of Middle temporo-frontal and Deep network was significantly decreased in autism spectrum disorder. Finally, the correlation analysis showed that the white matter and white-matter functional network connectivity between the Middle temporo-frontal network and others networks and the spontaneous activity of the Deep network were significantly correlated with the Social Responsiveness Scale scores of autism spectrum disorder. Together, our findings indicate that changes in the white-matter functional networks are associated behavioral deficits in autism spectrum disorder.
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