细胞毒性T细胞
生物
穿孔素
效应器
CD8型
免疫学
脐带血
T细胞
细胞生物学
免疫系统
遗传学
体外
作者
Haoting Hsu,Claudio Zanettini,Modupe Coker,Sarah Boudová,David Rach,Godfrey Mvula,Titus Divala,Randy G. Mungwira,Francesca Boldrin,Giulia Degiacomi,Laura Cioetto Mazzabò,Riccardo Manganelli,Miriam K. Laufer,Yuji Zhang,Luigi Marchionni,Cristiana Cairo
标识
DOI:10.1016/j.cellimm.2023.104797
摘要
Vγ9Vδ2 T lymphocytes are programmed for broad antimicrobial responses with rapid production of Th1 cytokines even before birth, and thus thought to play key roles against pathogens in infants. The process regulating Vδ2 cell acquisition of cytotoxic potential shortly after birth remains understudied. We observed that perforin production in cord blood Vδ2 cells correlates with phenotypes defined by the concomitant assessment of PD-1 and CD56. Bulk RNA sequencing of sorted Vδ2 cell fractions indicated that transcripts related to cytotoxic activity and NK function are enriched in the subset with the highest proportion of perforin+ cells. Among differentially expressed transcripts, IRF8, previously linked to CD8 T cell effector differentiation and NK maturation, has the potential to mediate Vδ2 cell differentiation towards cytotoxic effectors. Our current and past results support the hypothesis that distinct mechanisms regulate Vδ2 cell cytotoxic function before and after birth, possibly linked to different levels of microbial exposure.
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