The Landscape of m6A RNA Methylation in Skin Diseases

Abstract Skin diseases encompass a diverse range of conditions with significant psychological and physiological impacts. N6-methyladenosine (m6A) RNA methylation is a key epitranscriptomic modification that regulates gene expression by influencing RNA stability, splicing, translation, export, and degradation. Recent studies have highlighted the crucial role of m6A modification in the pathogenesis and progression of various skin diseases. M6A modification affects critical biological processes of the skin, such as inflammation, immune response, and cellular aging. This review systematically explores the landscape of m6A modification in non-tumor skin diseases, elucidating its regulatory roles and therapeutic implications, including wound healing, scar and keloid, skin aging, psoriasis, systemic lupus erythematosus, acne vulgaris, rosacea, chronic actinic dermatitis, and scleroderma. The intricate mechanisms of m6A modification can lead to the development of novel diagnostic biomarkers and therapeutic strategies, ultimately improving patient outcomes.