多发性硬化
实验性自身免疫性脑脊髓炎
髓源性抑制细胞
免疫学
发病机制
医学
髓样
人口
炎症
脑脊髓炎
抑制器
癌症
环境卫生
内科学
作者
Qianling Jiang,Jielin Duan,Luc Van Kaer,Guan Yang
标识
DOI:10.14336/ad.2023.0323-1
摘要
Myeloid-derived suppressor cells (MDSCs), a heterogeneous cell population that consists of mostly immature myeloid cells, are immunoregulatory cells mainly characterized by their suppressive functions. Emerging findings have revealed the involvement of MDSCs in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). MS is an autoimmune and degenerative disease of the central nervous system characterized by demyelination, axon loss, and inflammation. Studies have reported accumulation of MDSCs in inflamed tissues and lymphoid organs of MS patients and EAE mice, and these cells display dual functions in EAE. However, the contribution of MDSCs to MS/EAE pathogenesis remains unclear. This review aims to summarize our current understanding of MDSC subsets and their possible roles in MS/EAE pathogenesis. We also discuss the potential utility and associated obstacles in employing MDSCs as biomarkers and cell-based therapies for MS.
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