Evaluation of the association between tetracycline-class antibiotic use in patients with acne and idiopathic intracranial hypertension risk: a population-level cohort study

We conducted a population-based retrospective cohort study on the TriNetX US Collaborative Network to investigate whether tetracycline-class antibiotic exposure is associated with idiopathic intracranial hypertension (IIH) development in people with acne. Doxycycline exposure conferred a significantly decreased risk of IIH compared with minocycline, and minocycline exposure was associated with a significantly increased risk of IIH compared with nonsystemic acne treatment. Our findings underscore the need to carefully consider the use of minocycline in acne treatment.