Electrochemical difunctionalization of isocyanides by a three-component reaction cascade Mumm rearrangement: Rapid access to sulfur-containing imides

An efficient and practical electrochemical method for the three-component reaction cascade Mumm rearrangement of imides has been developed using a simple undivided cell with carbon electrodes at room temperature, which provides a useful strategy for the rapid synthesis of sulfur-containing imides with broad substrate scope and high functional tolerance. It is a rare example of in situ generation of O -acyl isoamide precursor for Mumm rearrangement. An efficient and practical electrochemical method for the three-component reaction cascade Mumm rearrangement of imides has been developed using a simple undivided cell with carbon electrodes at room temperature, which provides a useful strategy for the rapid synthesis of sulfur-containing imides with broad substrate scope and high functional tolerance. It is a rare example of in situ generation of O -acyl isoamide precursor for Mumm rearrangement.