SHLP2 alleviates allergic asthma by inhibiting ETV5/GSDMD signaling pathway-mediated pyroptosis

Overexpression of ETV5 improved mitochondrial function and reduced pyroptosis in bronchial epithelial cells. However, exogenous SHLP2 supplementation failed to reverse the exacerbation of HDM-induced lung inflammation and airway barrier damage caused by ETV5 knockout in mice. These findings highlight SHLP2 as a key ETV5/GSDMD signaling pathway regulator, inhibiting pyroptosis and mitigating AA progression.