p38丝裂原活化蛋白激酶
生物
磷酸化
细胞生物学
磷酸酶
激酶
滞育
蛋白激酶A
Cdc25型
活性氧
生物化学
细胞周期蛋白依赖激酶1
植物
幼虫
细胞凋亡
细胞周期
作者
Xiao-long SU,Zhi-Ren Su,Wei‐Hua Xu
标识
DOI:10.1016/j.bbamcr.2022.119389
摘要
Diapause in insects is akin to dauer in Caenorhabditis elegans and hibernation in vertebrates, characterized by metabolic depression and lifespan extension. Previous studies have shown that reactive oxygen species (ROS) and hypoxia-inducible factor-1α (HIF-1α) in brains of diapause-destined pupae are more abundant than those in nondiapause-destined pupae in Helicoverpa armigera, but the ROS regulating HIF-1α activity remain unknown. Here, we showed that high ROS levels in brains of diapause-destined pupae resulted in low casein kinase 2 (CK2) activity and that downregulation of CK2 caused low expression of mitogen-activated protein kinase phosphatase 3 (MKP3), which is an inhibitor of p-p38. Thus, high p-p38 levels accumulate to improve HIF-1α activity via activating HIF-1α phosphorylation at the S732 residue to regulate insect diapause. This is the first report showing that a new pathway, ROS-CK2-MKP3-p38, regulates HIF-1α activity for lifespan in insects.
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