Baseline correction using a deep-learning model combining ResNet and UNet

infrared, Raman, and mass spectroscopy, have baseline drifts due to fluorescence or other reasons, which have an adverse impact on subsequent analyses. Therefore, several researchers have proposed the use of various baseline-correction methods to address the aforementioned issue. However, most baseline-correction methods require manual adjustment of the parameters to achieve desirable performance. In this study, we propose a baseline-correction method based on a deep-learning model that combines ResNet and UNet. The method uses a deep-learning model trained with simulated spectral data to perform baseline corrections and eliminates the need for manual parameter adjustments. Based on the results of the qualitative and quantitative analyses of the simulated spectral data and actual Raman spectra, the proposed method is easier to apply and has better performance compared to the existing methods. As the proposed method can be applied to Raman spectra and other spectra, it is expected to be widely used.