EFFECTS OF OXIDATION AND HYDROLYSIS ON THE CHEMICAL STABILITY OF DRUGS

A guide for the chemical stability of drugs to hydrolysis and oxidation is presented. This chapter covers a general discussion on stability, oxidation and hydrolysis. Various functional groups and structural moieties present in drug molecules, which can undergo hydrolysis, and oxidation were discussed. Solid, semisolid and liquid dosage forms are discussed with formulation changes. Major strategies have been explained for the prevention of oxidation and hydrolysis, which have a major role in causing degradation of the pharmaceutical dosage forms.