医学
球虫病
免疫学
白细胞介素12受体,β1亚单位
球虫病
白细胞介素
细胞因子
皮肤病科
作者
Donald C. Vinh,B. Schwartz,Amy P. Hsu,D. J. Miranda,Patricia Valdez,Danielle Fink,Kristina Lau,Debra Long-Priel,Douglas B. Kuhns,Gülbû Uzel,Stefania Pittaluga,Susan Hoover,J N Galgiani,Steven M. Holland
摘要
Severe disseminated Coccidioides is rare while localized, contained disease is common. We report a family with disseminated coccidioidomycosis due to a novel homozygous C186Y mutation in interleukin (IL)-12 receptor β1. This family confirms the centrality of the IL-12/IFN-γ axis to human immunity to Coccidioides spp.
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