纳米技术
材料科学
表征(材料科学)
扫描共焦电子显微镜
环境扫描电子显微镜
扫描离子电导显微镜
纳米载体
脂质体
扫描电子显微镜
显微镜
共焦显微镜
扫描探针显微镜
透射电子显微镜
药物输送
光学
物理
复合材料
作者
Barbara Ruozi,Daniela Belletti,Andrea Tombesi,Giovanni Tosi,Lucia Bondioli,Flavio Forni,Maria Angela Vandelli
摘要
An outstanding aspect of pharmaceutical nanotechnology lies in the characterization of nanocarriers for targeting of drugs and other bioactive agents.The development of microscopic techniques has made the study of the surface and systems architecture more attractive.In the field of pharmaceutical nanosystems, researchers have collected vital information on size, stability, and bilayer organization through the microscopic characterization of liposomes.This paper aims to compare the results obtained by atomic force microscopy, environmental scanning electron microscopy, transmission electron microscopy, and confocal laser scanning microscopy to point out the limits and advantages of these applications in the evaluation of vesicular systems.Besides this comparative aim, our work proposes a simple confocal laser scanning microscopy procedure to rapidly and easily detect the liposomal membrane.
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