化学
羟醛反应
吡咯烷
苯并咪唑
醛
酮
胺化
催化作用
有机化学
有机催化
还原胺化
废止
布朗斯特德-洛瑞酸碱理论
羟醛缩合
对映选择合成
作者
Éric Lacoste,Émilie Vaique,Muriel Berlande,Isabelle Pianet,Jean‐Marc Vincent,Yannick Landais
标识
DOI:10.1002/ejoc.200600664
摘要
Abstract A new chiral benzimidazole‐pyrrolidine has been devised, which exhibits excellent activities in aminocatalyzed aldol reactions, leading to aldol products in high yields and enantioselectivities in the presence of an equimolar amount of a Brönsted acid. This organocatalyst has demonstrated remarkable reactivities in aldol processes even with equimolar amounts of aldehyde and ketone in THF. A discussion of the role of the Brönsted acid as a co‐catalyst is provided along with some applications of this new class of organocatalyst in Robinson annelation and α‐amination processes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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